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Observatory · observe first

Biotechnology

Biotechnology is losing market weight. Gained weight for 2 consecutive months.

Historical time machine
Historical observation
20182026
Reversing upwardBroad

The loss is shared across much of the industry.

Universe weight
2.04%
$0.91T
12-month change
-0.33 pp
6-month change
-0.22 pp
3-month change
+0.20 pp
Company participation
63%
above their 6M weight average

Where did the weight change come from?

12-month contribution in universe percentage points · contributions add to the industry change

Sub-industries
Company attribution
All other companies-0.216 pp
Industry total-0.329 pp

The three largest same-direction contributors explain 65% of gross losses. Opposing contributions can make an individual company’s change larger than the industry’s net change.

How has it moved through history?

Share of matched S&P 500 members

Mar 2020 – Feb 2025 · market weight (%)

0.11.53.020212022202320242025

Relative performance

Industry return versus ACWI · no future data shown

789611520212022202320242025

Is participation broad or concentrated?

Actual constituent counts at this date, not the legacy synthetic breadth proxy

Above their 3M universe-weight average75%
Above their 6M universe-weight average63%
Above their 12M universe-weight average63%
Top 5 share of current industry market cap94.9%

This is size concentration, not contribution to the 12-month change. The attribution above measures the latter.

Evidence can disagree

Independent dimensions · no combined score or bullish/bearish verdict

Allocation · 12M-0.33 pp
Relative strength · 12M-1.7%
Price index return · 12M+13.3%
Earnings revisions · unavailable0.0
Allocation lost weight while relative performance fell. At least half of constituents are above their 6M weight average. These observations need not agree.
Other evidence and availability

Valuation data: unavailable; shown as zero placeholder.

Attention data: unavailable; shown as zero placeholder.

Actual fund flows: unavailable. No ETF, mutual-fund or institutional flow feed is connected.

Volume / turnover: unavailable in this dataset.

Follow the contribution to individual companies

Sorted by absolute 12-month weight contribution, not investment merit

CompanySub-industryCountryUniverse weight12M contribution12M price returnRevisions
Regeneron Pharmaceuticals →
REGN
BiotechnologyUnited States0.147%-0.113 pp-27.6%0.0
Moderna →
MRNA
BiotechnologyUnited States0.027%-0.074 pp-66.4%0.0
AbbVie →
ABBV
BiotechnologyUnited States0.825%-0.066 pp+23.1%0.0
Gilead Sciences →
GILD
BiotechnologyUnited States0.318%+0.061 pp+65.0%0.0
Amgen →
AMGN
BiotechnologyUnited States0.370%-0.050 pp+15.9%0.0
Biogen →
BIIB
BiotechnologyUnited States0.046%-0.044 pp-35.3%0.0
Vertex Pharmaceuticals →
VRTX
BiotechnologyUnited States0.276%-0.036 pp+14.0%0.0
Incyte →
INCY
BiotechnologyUnited States0.032%-0.006 pp+25.9%0.0
Underlying monthly industry observations
MonthWeight1M change3M change6M change12M changeRelative return · 12M
Feb 20252.041%+0.190 pp+0.196 pp-0.221 pp-0.329 pp-1.7%
Jan 20251.850%+0.055 pp-0.277 pp+0.203 pp-0.658 pp-16.4%
Dec 20241.795%-0.050 pp-0.328 pp+0.167 pp-0.608 pp-14.3%
Nov 20241.845%-0.282 pp-0.417 pp+0.242 pp-0.449 pp-8.0%
Oct 20242.127%+0.004 pp+0.480 pp-0.148 pp-0.341 pp-3.6%
Sep 20242.123%-0.139 pp+0.494 pp-0.231 pp-0.405 pp-6.3%
Aug 20242.262%+0.615 pp+0.658 pp-0.108 pp-0.146 pp+2.8%
Jul 20241.647%+0.019 pp-0.628 pp-0.861 pp+0.028 pp+8.5%
Jun 20241.628%+0.025 pp-0.725 pp-0.774 pp-0.019 pp+4.6%
May 20241.603%-0.672 pp-0.766 pp-0.690 pp-0.163 pp-2.9%
Apr 20242.275%-0.078 pp-0.233 pp-0.193 pp-0.335 pp-10.9%
Mar 20242.353%-0.016 pp-0.049 pp-0.174 pp-0.336 pp-10.5%
Feb 20242.369%-0.139 pp+0.076 pp-0.039 pp-0.275 pp-8.6%
Jan 20242.508%+0.106 pp+0.040 pp+0.890 pp-0.174 pp-3.2%
Dec 20232.402%+0.109 pp-0.125 pp+0.756 pp-0.493 pp-15.8%
Nov 20232.294%-0.175 pp-0.114 pp+0.527 pp-0.520 pp-18.2%
Oct 20232.468%-0.059 pp+0.850 pp-0.142 pp-0.259 pp-12.4%
Sep 20232.527%+0.119 pp+0.881 pp-0.163 pp-0.121 pp-4.5%
Aug 20232.408%+0.789 pp+0.641 pp-0.237 pp+0.016 pp+1.6%
Jul 20231.619%-0.028 pp-0.992 pp-1.064 pp-0.790 pp-3.2%
Jun 20231.647%-0.120 pp-1.043 pp-1.248 pp-1.112 pp-11.3%
May 20231.766%-0.844 pp-0.878 pp-1.047 pp-0.805 pp+1.8%
Apr 20232.610%-0.079 pp-0.072 pp-0.116 pp+0.110 pp+11.9%
Mar 20232.690%+0.045 pp-0.205 pp+0.041 pp+0.179 pp+17.8%
Feb 20232.645%-0.038 pp-0.169 pp+0.252 pp+0.258 pp+23.6%
Jan 20232.683%-0.212 pp-0.044 pp+0.274 pp+0.351 pp+27.8%
Dec 20222.895%+0.081 pp+0.246 pp+0.137 pp+0.567 pp+40.6%
Nov 20222.814%+0.087 pp+0.421 pp+0.243 pp+0.442 pp+38.1%
Oct 20222.727%+0.078 pp+0.319 pp+0.227 pp+0.379 pp+41.8%
Sep 20222.649%+0.256 pp-0.110 pp+0.138 pp+0.136 pp+23.3%
Aug 20222.392%-0.016 pp-0.179 pp+0.006 pp-0.174 pp+7.9%
Jul 20222.408%-0.350 pp-0.092 pp+0.076 pp-0.142 pp+9.2%
Jun 20222.758%+0.187 pp+0.248 pp+0.430 pp+0.638 pp+17.6%
May 20222.571%+0.071 pp+0.185 pp+0.199 pp+0.495 pp+11.4%
Apr 20222.500%-0.010 pp+0.168 pp+0.152 pp+0.416 pp+7.5%
Mar 20222.511%+0.124 pp+0.183 pp-0.002 pp+1.383 pp+1.5%
Feb 20222.386%+0.054 pp+0.014 pp-0.180 pp+1.280 pp-3.3%
Jan 20222.332%+0.004 pp-0.016 pp-0.219 pp+0.958 pp-10.9%
Dec 20212.328%-0.044 pp-0.184 pp+0.208 pp+0.063 pp-8.3%
Nov 20212.372%+0.024 pp-0.194 pp+0.296 pp+0.023 pp-11.0%
Oct 20212.348%-0.164 pp-0.203 pp+0.264 pp-0.078 pp-16.0%
Sep 20212.512%-0.054 pp+0.392 pp+1.384 pp+2.510 pp-17.0%
Aug 20212.566%+0.016 pp+0.490 pp+1.460 pp+2.563 pp-16.2%
Jul 20212.550%+0.430 pp+0.466 pp+1.176 pp+2.548 pp-21.1%
Jun 20212.121%+0.045 pp+0.993 pp-0.144 pp+2.117 pp-26.3%
May 20212.076%-0.008 pp+0.969 pp-0.273 pp+2.073 pp-29.3%
Apr 20212.084%+0.956 pp+0.710 pp-0.342 pp-1.011 pp-29.6%
Mar 20211.128%+0.021 pp-1.137 pp+1.125 pp+1.125 pp-26.4%
Feb 20211.107%-0.267 pp-1.242 pp+1.104 pp+1.105 pp-15.6%
Jan 20211.374%-0.891 pp-1.052 pp+1.371 pp-1.006 pp+0.9%
Dec 20202.265%-0.084 pp+2.262 pp+2.262 pp-0.288 pp-7.7%
Nov 20202.349%-0.077 pp+2.346 pp+2.346 pp-0.272 pp-7.7%
Oct 20202.426%+2.423 pp+2.423 pp-0.669 pp-0.055 pp+2.1%
Sep 20200.003%-0.000 pp-0.000 pp+0.000 pp-2.317 pp+18.0%
Aug 20200.003%+0.000 pp-0.000 pp+0.001 pp-2.360 pp+18.2%
Jul 20200.003%-0.000 pp-3.092 pp-2.378 pp-2.270 pp+29.3%
Jun 20200.003%-0.000 pp+0.001 pp-2.550 pp-2.400 pp+34.7%
May 20200.003%-3.092 pp+0.001 pp-2.618 pp-2.469 pp+35.3%
Apr 20203.095%+3.092 pp+0.714 pp+0.614 pp+0.599 pp+38.6%
Mar 20200.003%+0.000 pp-2.550 pp-2.317 pp-2.701 pp+27.5%
How are these descriptive states defined?

Gaining / losing: 12-month weight change above +0.005pp / below −0.005pp. Direction and speed are separate dimensions, not mutually exclusive recommendations.

Accelerating / slowing: compare the most recent 3M change with the preceding 3M change. Accelerating means a positive change speeds up by >0.02pp. Slowing means the magnitude of movement declines by >0.02pp. A falling industry can also slow.

Reversing: the last two 3M changes have opposite signs, outside a ±0.005pp tolerance. Persistence counts consecutive same-direction monthly changes.

Broad / concentrated: company attribution, not a market-cap concentration shortcut. Concentrated means the three largest same-direction contributors account for ≥70% of gross same-direction changes; otherwise broad requires ≥60% of constituents moving with the industry. Other cases are mixed.

Weights use matched S&P 500 members’ market-cap estimates, based on SEC-reported shares available by each month-end and monthly closing prices. Companies without a matched price or share record are omitted, so the denominator is the matched sample rather than every index member. These are not official float-adjusted S&P weights. Flow is not measured.